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KMID : 0984920180200010023
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Journal of Skin Barrier Research
2018 Volume.20 No. 1 p.23 ~ p.30
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Role of Ceramide and Its Metabolites in the Regulation of Epidermal Barrier Function
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Jeong Se-Kyoo
Shin Kyong-Oh
Park Kyung-Ho
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Abstract
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Ceramide is a main epidermal lipid and is composed of long-chain aminoalcohol and amide-linked fatty acids, whose chain lengths are 16-20 and 16-36, respectively. Emerging evidences demonstrated that ceramide plays a primary structural role in forming epidermal permeability barrier. In addition, ceramide and its metabolites, including sphingosine-1-phosphate, serve as signaling lipid to modulate multiple cellular functions, e.g., proliferation, differentiation, and apoptosis, as well as epidermal antimicrobial barrier. Here, we describe the signaling roles and current knowledge of ceramide and its metabolites in the regulation of epidermal barrier function.
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KEYWORD
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Ceramide, Epidermal barrier function, Signaling
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